Systematic evaluation of the association between hemoglobin levels and metabolic profile implicates beneficial effects of hypoxia

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Systematic evaluation of the association between hemoglobin levels and metabolic profile implicates beneficial effects of hypoxia Systematic evaluation of the association between hemoglobin levels and metabolic profile implicates beneficial effects of hypoxia

Abstract Activation of the hypoxia-inducible factor (HIF) pathway reprograms energy metabolism. Hemoglobin (Hb) is the main carrier of oxygen. Using its normal variation as a surrogate measure for hypoxia, we explored whether lower Hb levels could lead to healthier metabolic profiles in mice and humans (n = 7175) and used Mendelian randomization (MR) to evaluate …The post Systematic evaluation of ..
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